Time Lapse incubators for embryos

Are Time-Lapse Multiroom Incubators the Key to Optimal Embryo Culture in IVF Laboratories?

Time-lapse culture is the most modern type of embryo culture system available in the IVF industry. This culture system made it possible to have zero disturbance during the whole embryo culture period while having all the data needed to properly annotate embryos outside its desired culture conditions. This technology also made it possible to identify markers to perform better embryo selection in order to achieve pregnancy in the shortest time possible.

MIRI® Time-Lapse Incubator

The MIRI® Time-Lapse Incubator is a multiroom incubator with a built-in camera and microscope. Designed and manufactured in the EU, the MIRI® Time-Lapse Incubator provides high quality time-lapse images of embryos developing in "real-time" without having to remove the embryos from the safety of the incubation chamber for manual microscopy. Time-lapse embryo monitoring provides detailed morphokinetic data throughout embryo development, which is not available on routine spot microscopic evaluation. This allows all important events to be observed, helping to identify healthy embryos with the highest probability of implantation, with the aim of achieving higher pregnancy rates 

Timelapse time lapse time-lapse EmbryoAnimal IVF Time-LapseFor Time-Lapse in Human & Animal IVF

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Never miss a significant event in embryo development with the MIRI® Time-lapse Incubator.

This YouTube video presents the Miri TL time-lapse incubator, a device for undisturbed embryo culture with real-time imaging, available in two variants with six or twelve chambers. I

t features continuous gas recirculation, temperature sensors, independent gas sampling ports, and optional continuous pH monitoring, with a capacity of up to 168 embryos.

Six or twelve chambers for your MIRI® Time-Lapse Incubator

miri tl6 time-lapse embryo incubator for ivf in-vitro fertilization

Miri TL-6

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Miri TL-12

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Features

Independent chambers Timelapse Multiroom incubator for embryo

Unique Incubation Environment: With 6 (TL6) / 12 (TL12) individual chambers wherein one patient can be designated per chamber to avoid cross-contamination. The time-lapse in a chamber continues undisturbed even if the neighboring chambers are opened. Also, one can set individual temperature set-point for each chamber.

Time-Lapse Monitoring in Timelapse Multiroom incubator for embryo

Time-lapse video generated from images allows objective and reliable scoring and annotation of embryos for better prediction of future developmental and implantation potential. The MIRI® Time-Lapse Incubator is a multiroom incubator with a built-in camera and microscope. Designed and manufactured in EU, the MIRI® Time-Lapse Incubator provides high quality time-lapse images of embryos developing in "real-time"

Heated Lid in Timelapse Multiroom incubator for embryo

Excellent uniformity between the top and bottom lid. Heated chamber lids prevent condensation, enhance temperature regulation/recovery, and ensure temperature uniformity between the top and bottom of the chamber.

Fast temperature and gas recovery Timelapse Multiroom incubator for embryo

Excellent Recovery Time: The MIRI® TL has excellent recovery rates:

Temperature recovery <1 min
Gas recovery <3 mins.

Easy External Gas and Temperature Validation Timelapse Multiroom incubator for embryo

Gas sampling ports for each chamber and independent PT-1000 sensors allow external quality evaluation of gas levels and temperature in each chamber.

Superior Gas System Timelapse Multiroom incubator for embryo

Built-in gas mixer for tri-gas, an advanced gas regulation system, and HEPA-VOC filtered recirculation allows precise gas level control and a lower gas consumption.
UV-sterilization of recirculating gas ensures biological safety of embryos.

Touchscreen User friendly interface for Time-lapse incubator for embryo

Touchscreen control panel with intuitive menu to manage configuration of the device

Continually monitors and documents gas flow, gas concentration and pressure, temperature regulation.

Culture coin dish Esco MIRI-TL Timelapse Embryo

Specially designed culture dish, the CultureCoin, allows each chamber to culture 14 embryos, giving a total capacity of 84 embryos for the TL6 and 168 embryos for the TL12.

SAFE Sens integration for continuous pH monitoring without opening the chamber of time-lapse incubator for embryo

Optional SAFE Sens integration for continuous pH monitoring without opening the chamber.

MIRI® TL Viewer Software and MIRI® TL Server play time-laps embryo patient monitoring alarm incubator status

The MIRI® TL family’s multiroom IVF incubators Viewer software is a tool that helps users process data from the MIRI® TL6 and MIRI® TL12 multiroom IVF incubators, and includes a complete patient database. The software assigns a unique identifier to each patient, allows for annotation of development and comparison of embryos, plays time-lapse videos, and displays incubator status and alarm conditions. Theses are excellent tools to review, annotate and compare morphokinetic parameters of embryos, as well as export data for retrospective analysis. Assist Function in the software registers the first three divisions automatically. This is a unique feature of the MIRI® TL User-friendliness of MIRI® TL software provides flexibility and versatility to the embryologists to add or edit events or sub-events.

AI-Powered CHLOE EQ™: Revolutionizing Reproductive Decision Support

Embarking on the frontier of assisted reproductive technology (ART), Esco Medical has partnered with Fairtility's AI-powered Chloe EQ (Cultivating Human Life through Optimal Embryos) as a decision support for Miri Time-Lapse Incubators. This collaboration underscores our commitment to leveraging cutting-edge AI for more precise and efficient embryo monitoring in in vitro fertilization (IVF). Join us on the journey where innovation meets compassion, shaping the future of ART for those seeking to build their families. Explore further by watching our short video to discover the transformative potential of AI in reproductive support.

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Simple Guide on how to operate the MIRI® TL

The Esco Medical CultureCoin® is an IVF culture dish designed specifically for the MIRI® TL time-lapse incubators. The CultureCoin® is a single-use, gamma-sterilized culture dish that has oxygen plasma-treated surfaces for effective prevention of bubble formation. Its ergonomic design makes it easy for embryologists to load a total of 14 embryos while being able to safely and securely handle them inside the incubator. This culture well features a 300µm, optically clear area for embryo placement which is optimized for microscopy.

CultureCoin preparation media oil IVF workstation microscope bubbles equilibration wells cover

1. Preparation of the CultureCoin®, the media, and oil must be done a day before loading the embryos.
2. Before loading the CultureCoin® with the media and oil, see to it that you have pre-equilibrated the following inside a humidified incubator:
The culture media and the CultureCoin® for 4 to 6 hours
The Overlay oil for 1 to 2 days.
3. Always ensure that you work inside an IVF Workstation. Load the CultureCoin® with the 25ul of media under the microscope. (Do not inject the media directly on the bottom of the well.)
4. Fill it on its wall and remove any visible bubbles from the media with a stripper tip.
5. Cover the media with 3 - 3.5 ml of pre-heated oil.
6. Put the CultureCoin® with the lid inside an incubator and leave it for more than 12 hours for equilibration.

Loading the Embryos in a CultureCoin

1. After equilibration, check for air bubbles in the culture wells. Remove any bubbles with a stripper tip.
2. Load the embryos into the center of the filled microwells with a plastic stripper tip.
3. Place the embryo at the center of the well.
4. Once done, carefully put the embryo loaded CultureCoin® inside an unoccupied MIRI® TL chamber.
5. Select patient then select/deselect active positions and start Time-Lapse when ready.

Embryo Annotation MIRI-TL Viewer Assist tool AI Cleavage Artificial Intelligence

1. On the MIRI® TL Viewer Home Screen, select “TimeLapses” and look for the patient to open time-lapse videos. A revolver view with the time-lapse video of each of the14 wells in the CultureCoin® will be displayed.
2. Select an embryo to annotate. The embryo will be maximized at the center. The annotation system is structured around the “events” that are located on the left of the wheel.
3. You can also use the ASSIST tool to automatically annotate the first 4 cleavage events.

Software helps selecting the most viable embryo IVF Time-lapse

1. The MIRI® TL Viewer software is equipped with sophisticated tools to help you evaluate and select the most viable embryo after completely annotating all embryos.
2. The Compare Tool will let you do a side-by-side comparison of two embryos. Two embryo videos can be played independently or linked together for comparison.
3. The “Summary” tool will allow you to compare all embryos in an informative and graphical way. It will let you compare embryo developmental timings and which one develops closely with the ideal timings.
4. Once the selection process has been completed or a decision has been made, click the green check icon in the upper left corner. After clicking it, a drop-down list of the desired status will appear.
5. Assign a corresponding color that indicates the decision in each well: Green for “transfer”, Red for “discard”, and Blue for “freeze”. The colored ring will appear around the well to indicate the decision made. You can also click the “Dish Map” icon to visually map the decision that has been made.

Literature & Resources: Download MIRI® TL user manuals and certificates

Ordering Information for MIRI® TL Instruments, Accessories and Consumables

Part numbers for MIRI® Time-Lapse Incubators


Item CodeModel CodeDescription
Unit
2070091MRI-TL-MN-6C-8MIRI® Time-Lapse Incubator, Mini, 6 Chambers, 230 V, 50/60 Hz
2070098MRI-TL-MN-6C-SS-8MIRI® Time-Lapse Incubator, Mini, 6 chambers with SAFE Sens, 230 V, 60/60 Hz
2070100MRI-TL12C-8MIRI® Time-Lapse Incubator, 12 Chambers, 230 V, 50/60 Hz
2070114MRI-TL-SS-12C8MIRI® Time-Lapse Incubator, 12 Chambers, 230V 50/60Hz, with SAFE Sens
Accessories  
1320011MRA-1007HEPA + VOC filter (to be replaced every 3 months)
1320088MRI-CCCultureCoin® for Time-Lapse of 14 embryos (25 pcs. per pack)
1320045MRI-GAMIRI® GA CO2 /O2 & Temperature Validation Unit, 115V/ 230V

 


Item CodeModel CodeDescription
2070042MRI-VIEWERMIRI® Time-Lapse Viewer
1320095MRI-SERVERMIRI® Time-Lapse Server


Our products

ESCO LIFE SCIENCES

MIRI® TL-12 Time-Lapse Mini Benchtop Incubator, 12 Chambers, 230V 50/60Hz

Reference : ESC-2070100

The MIRI® Time-Lapse Incubator is a multiroom incubator with a built-in camera and microscope. Designed and manufactured in EU, the MIRI® Time-Lapse Incubator provides high quality time-lapse images of embryos developing in "real-time" without having to remove the embryos from the safety of the incubation chamber for manual microscopy. Time-lapse embryo monitoring provides detailed morphokinetic data throughout embryo development, which is not available on routine spot microscopic evaluation. This allows all important events to be observed, helping IVF labs to identify healthy embryos with the highest probability of implantation, with the aim of achieving higher pregnancy rates.


FEATURES:
Completely independent chambers
6 (TL6) / 12 (TL12) independent chambers with precise temperature and gas regulation: Opening any chamber does not affect the environment in other chambers.

Time-lapse monitoring
Time-lapse video generated from images allows objective and reliable scoring and annotation of embryos for better prediction of future developmental and implantation potential

Heated lid
Excellent uniformity between the top and bottom lid.Heated chamber lids prevent condensation, enhance temperature regulation/recovery, and ensure temperature uniformity between the top and bottom of the chamber.

Fast temperature and gas recovery
• Temperature recovery <1 min
• Gas recovery <3 mins.

Superior gas system
• Built-in gas mixer for tri-gas, an advanced gas regulation system, and HEPA-VOC filtered recirculation allows precise gas level control and a lower gas consumption.
• UV-sterilization of recirculating gas ensures biological safety of embryos.
Easy external gas and temperature validation
Gas sampling ports for each chamber and independent PT-1000 sensors allow external quality evaluation of gas levels and temperature in each chamber.

User friendly interface
Touchscreen control panel with intuitive menu to manage configuration of the device

The CultureCoin
Specially designed culture dish, the CultureCoin, allows each chamber to culture 14 embryos, giving a total capacity of 84 embryos for the TL6 and 168 embryos for the TL12.

MIRI® TL Data Logger
Continually monitors and documents gas flow, gas concentration and pressure, temperature regulation.

Continuous pH monitoring
Optional SAFE Sens integration for continuous pH monitoring without opening the chamber.

MIRI® TL Viewer software and MIRI® TL Data Server
• Exponentially increase image and data storage capacity by adding the MIRI® TL Data Server.
• Combine MIRI® TL Viewer software platform to review, annotate and compare morphokinetic parameters of embryos, as well as export data for retrospective analysis.

ESCO LIFE SCIENCES

MIRI® TL-6 Time-Lapse Mini Benchtop Incubator, 6 Chambers, 230V 50/60Hz

Reference : ESC-2070091

The MIRI® Time-Lapse Incubator is a multiroom incubator with a built-in camera and microscope. Designed and manufactured in EU, the MIRI® Time-Lapse Incubator provides high quality time-lapse images of embryos developing in "real-time" without having to remove the embryos from the safety of the incubation chamber for manual microscopy. Time-lapse embryo monitoring provides detailed morphokinetic data throughout embryo development, which is not available on routine spot microscopic evaluation. This allows all important events to be observed, helping IVF labs to identify healthy embryos with the highest probability of implantation, with the aim of achieving higher pregnancy rates.


FEATURES:
Completely independent chambers
6 (TL6) / 12 (TL12) independent chambers with precise temperature and gas regulation: Opening any chamber does not affect the environment in other chambers.

Time-lapse monitoring
Time-lapse video generated from images allows objective and reliable scoring and annotation of embryos for better prediction of future developmental and implantation potential

Heated lid
Excellent uniformity between the top and bottom lid.Heated chamber lids prevent condensation, enhance temperature regulation/recovery, and ensure temperature uniformity between the top and bottom of the chamber.

Fast temperature and gas recovery
• Temperature recovery <1 min
• Gas recovery <3 mins.

Superior gas system
• Built-in gas mixer for tri-gas, an advanced gas regulation system, and HEPA-VOC filtered recirculation allows precise gas level control and a lower gas consumption.
• UV-sterilization of recirculating gas ensures biological safety of embryos.

Easy external gas and temperature validation
Gas sampling ports for each chamber and independent PT-1000 sensors allow external quality evaluation of gas levels and temperature in each chamber.

User friendly interface
Touchscreen control panel with intuitive menu to manage configuration of the device

The CultureCoin
Specially designed culture dish, the CultureCoin, allows each chamber to culture 14 embryos, giving a total capacity of 84 embryos for the TL6 and 168 embryos for the TL12.

MIRI® TL Data Logger
Continually monitors and documents gas flow, gas concentration and pressure, temperature regulation.

Continuous pH monitoring
Optional SAFE Sens integration for continuous pH monitoring without opening the chamber.

MIRI® TL Viewer software and MIRI® TL Data Server
• Exponentially increase image and data storage capacity by adding the MIRI® TL Data Server.
• Combine MIRI® TL Viewer software platform to review, annotate and compare morphokinetic parameters of embryos, as well as export data for retrospective analysis.

ESCO LIFE SCIENCES
CultureCoin® for MIRI® TL, 14 embryos per culture coin (per pack of 25)
Reference : ESC-1320088

CultureCoin® , a culture dish, exclusively designed for the MIRI® TL

One (1) MIRI ® TL chamber can hold one (1) CultureCoin®. Each dish can accommodate up to fourteen (14) embryos, each with a numbered well assignment. The MIRI® TL6 can hold up to 84 embryos, and the MIRI® TL12 up to 168 embryos.

Key Features

• Each embryo is cultured in its own stable environment.
• Ergonomic design for easy, safe, and secure handling of embryos.
• Independent well for pH measurements.
• Corona plasma-treated surface for the effective prevention of bubble formation.
• Gamma-sterilized.

ESCO LIFE SCIENCES
MIRI® TL-12 Time-Lapse Mini Benchtop Incubator, 12 Chambers, 230V 50/60Hz
Reference : ESC-2070100

The MIRI® Time-Lapse Incubator is a multiroom incubator with a built-in camera and microscope. Designed and manufactured in EU, the MIRI® Time-Lapse Incubator provides high quality time-lapse images of embryos developing in "real-time" without having to remove the embryos from the safety of the incubation chamber for manual microscopy. Time-lapse embryo monitoring provides detailed morphokinetic data throughout embryo development, which is not available on routine spot microscopic evaluation. This allows all important events to be observed, helping IVF labs to identify healthy embryos with the highest probability of implantation, with the aim of achieving higher pregnancy rates.


FEATURES:
Completely independent chambers
6 (TL6) / 12 (TL12) independent chambers with precise temperature and gas regulation: Opening any chamber does not affect the environment in other chambers.

Time-lapse monitoring
Time-lapse video generated from images allows objective and reliable scoring and annotation of embryos for better prediction of future developmental and implantation potential

Heated lid
Excellent uniformity between the top and bottom lid.Heated chamber lids prevent condensation, enhance temperature regulation/recovery, and ensure temperature uniformity between the top and bottom of the chamber.

Fast temperature and gas recovery
• Temperature recovery <1 min
• Gas recovery <3 mins.

Superior gas system
• Built-in gas mixer for tri-gas, an advanced gas regulation system, and HEPA-VOC filtered recirculation allows precise gas level control and a lower gas consumption.
• UV-sterilization of recirculating gas ensures biological safety of embryos.
Easy external gas and temperature validation
Gas sampling ports for each chamber and independent PT-1000 sensors allow external quality evaluation of gas levels and temperature in each chamber.

User friendly interface
Touchscreen control panel with intuitive menu to manage configuration of the device

The CultureCoin
Specially designed culture dish, the CultureCoin, allows each chamber to culture 14 embryos, giving a total capacity of 84 embryos for the TL6 and 168 embryos for the TL12.

MIRI® TL Data Logger
Continually monitors and documents gas flow, gas concentration and pressure, temperature regulation.

Continuous pH monitoring
Optional SAFE Sens integration for continuous pH monitoring without opening the chamber.

MIRI® TL Viewer software and MIRI® TL Data Server
• Exponentially increase image and data storage capacity by adding the MIRI® TL Data Server.
• Combine MIRI® TL Viewer software platform to review, annotate and compare morphokinetic parameters of embryos, as well as export data for retrospective analysis.

ESCO LIFE SCIENCES
MIRI® TL-6 Time-Lapse Mini Benchtop Incubator, 6 Chambers, 230V 50/60Hz
Reference : ESC-2070091

The MIRI® Time-Lapse Incubator is a multiroom incubator with a built-in camera and microscope. Designed and manufactured in EU, the MIRI® Time-Lapse Incubator provides high quality time-lapse images of embryos developing in "real-time" without having to remove the embryos from the safety of the incubation chamber for manual microscopy. Time-lapse embryo monitoring provides detailed morphokinetic data throughout embryo development, which is not available on routine spot microscopic evaluation. This allows all important events to be observed, helping IVF labs to identify healthy embryos with the highest probability of implantation, with the aim of achieving higher pregnancy rates.


FEATURES:
Completely independent chambers
6 (TL6) / 12 (TL12) independent chambers with precise temperature and gas regulation: Opening any chamber does not affect the environment in other chambers.

Time-lapse monitoring
Time-lapse video generated from images allows objective and reliable scoring and annotation of embryos for better prediction of future developmental and implantation potential

Heated lid
Excellent uniformity between the top and bottom lid.Heated chamber lids prevent condensation, enhance temperature regulation/recovery, and ensure temperature uniformity between the top and bottom of the chamber.

Fast temperature and gas recovery
• Temperature recovery <1 min
• Gas recovery <3 mins.

Superior gas system
• Built-in gas mixer for tri-gas, an advanced gas regulation system, and HEPA-VOC filtered recirculation allows precise gas level control and a lower gas consumption.
• UV-sterilization of recirculating gas ensures biological safety of embryos.

Easy external gas and temperature validation
Gas sampling ports for each chamber and independent PT-1000 sensors allow external quality evaluation of gas levels and temperature in each chamber.

User friendly interface
Touchscreen control panel with intuitive menu to manage configuration of the device

The CultureCoin
Specially designed culture dish, the CultureCoin, allows each chamber to culture 14 embryos, giving a total capacity of 84 embryos for the TL6 and 168 embryos for the TL12.

MIRI® TL Data Logger
Continually monitors and documents gas flow, gas concentration and pressure, temperature regulation.

Continuous pH monitoring
Optional SAFE Sens integration for continuous pH monitoring without opening the chamber.

MIRI® TL Viewer software and MIRI® TL Data Server
• Exponentially increase image and data storage capacity by adding the MIRI® TL Data Server.
• Combine MIRI® TL Viewer software platform to review, annotate and compare morphokinetic parameters of embryos, as well as export data for retrospective analysis.

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