Enhancing IVF Laboratory Success: A Commitment to Precision and Quality
In vitro fertilization (IVF) is one of several assisted reproductive techniques (ART) performed to treat infertility, and assist infertile couples to have a child. IVF is a process of fertilization where an egg is combined with sperm outside the body, in vitro ("in glass"). The process involves monitoring and stimulating a woman's ovulatory process, removing an ovum or ova (egg or eggs) from the woman's ovaries and letting sperm fertilize them in a liquid in a laboratory. After the fertilized egg (zygote) undergoes embryo culture for 2–6 days, it is implanted in the same or another woman's uterus, with the intention of establishing a successful pregnancy.
Analis, together with its partners, offers local support and expertise in state-of-the art equipment developed to support the actual and future needs of IVF laboratories.
Esco Medical is the leading manufacturer and innovator of high-quality equipment such as long-term embryo incubators and time-lapse incubators, ART workstations, anti-vibration tables and is continuously developing advanced technologies to meet the increasing demand of the IVF industry. The Miri Evidence Witnessing & Traceability Tool, and the use of artificial intelligence to assist embryo selection perfectly illustrate this.
The slightest deviation often results in non-optimal conditions for embryo growth and can lower pregnancy success.
Our primary focus is to aid fertility clinics and laboratories in increasing pregnancy success rates. This is why we understand that even the smallest details matter to the way in vitro fertilization is being performed.
Microscopy plays a central role in IVF workflows, from gamete selection and sperm evaluation to micromanipulation (ICSI / IMSI) and embryo observation. Carefully selected imaging systems are essential to ensure precision, stability, and efficient IVF workflows in assisted reproduction laboratories.
In-vitro fertilization (IVF) as a fertility treatment
IVF is a process of fertilizing an egg with a sperm outside the body, and then transferring the embryo into the uterus. IVF can help people who have difficulty conceiving naturally, such as those with blocked fallopian tubes, low sperm count, or genetic disorders. IVF has some risks and side effects, such as multiple pregnancies, ovarian hyperstimulation syndrome, or ectopic pregnancy. IVF also involves ethical and emotional issues, such as the disposal of unused embryos, the cost of treatment, or the psychological stress of the procedure.
MIRI® Evidence: Automated Witnessing System
Explore the pinnacle of IVF technology with Esco Medical's MIRI® Evidence. This advanced multiroom incubator is designed to revolutionize embryo culture environments, ensuring precise control for optimal development. With features such as individual chambers, real-time monitoring, and sophisticated data analytics, MIRI® Evidence enhances success rates, fosters healthier embryos, and streamlines workflow efficiency in reproductive laboratories. Dive into the future of assisted reproductive techniques with this cutting-edge solution.
Discover the videoLearn more
Artificial Intelligence : Revealing the power of A.I. in ART
Explore the synergy of Artificial Intelligence (AI) in Assisted Reproductive Technology (ART) on Esco Medical's page. Delve into how AI enhances embryo selection, optimizing success rates in fertility treatments. Learn about Esco Medical's commitment to incorporating AI into their innovative solutions, redefining the landscape of reproductive healthcare. Visit the pages for a glimpse into the future of AI-driven advancements in ART.
Learn about AI in ART from 1955 until todayHow Does AI Help in Embryo Selection ?
Accurate evaluation of embryo viability is crucial for optimizing IVF treatments and increasing pregnancy rates. Usually, embryologists depend on non-invasive visual evaluations of embryos or oocytes. This assessment emphasizes characteristics like morphology and dynamic development, particularly during the blastocyst stage. However, this evaluation is inherently subjective, leading to variability between different observers and even within the same observer, influenced by factors such as embryo scoring systems and the embryologists experience and expertise, ultimately affecting the final success rate. Moreover, the transfer of multiple embryos per cycle, while potentially increasing the success rate, raises the risk of complications like pre-eclampsia and maternal haemorrhage, as well as the likelihood of multiple pregnancies.
The integration of AI with automated morphological analysis of embryos or blastocysts presents an enticing solution. In 2012, Santos Filho and colleagues presented a semi-automated grading technique. This method involved tasks such as image segmentation and classification specifically applied to human blastocyst images. The researchers employed SVM classifiers to evaluate the inner cell mass (ICM) and trophectoderm (TE) quality. Through an analysis of fractal dimensions and mean thickness in TE and ICM image textures, they successfully characterized the crucial morphological attributes of the blastocyst. Additionally, optimizing microscope settings, such as enhancing contrast and delineating individual features more distinctly, may further refine image analysis.
Adapted from: JM Raimundo, P Cabrita, "Artificial intelligence at assisted reproductive technology," Procedia Computer Science, Volume 181, 2021, Pages 442-447, ISSN 1877-0509, DOI: 10.1016/j.procs.2021.01.189. Full Article.
Which Imaging Systems and Solutions Are Recommended for ICSI / IMSI in IVF?
Intracytoplasmic Sperm Injection (ICSI) and Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) demand optical precision and system stability. The EVIDENT IX73 ICSI / IMSI inverted microscope provides high-contrast imaging for these delicate procedures, with relief contrast optics for oocytes and sperm in plastic culture dishes, and optional DIC or polarized light modules for non-invasive spindle observation.
View IX73 specifications and download brochure
For complementary observation and quality control tasks in IVF laboratories, the EVIDENT BX53 upright microscope offers versatile, high-resolution imaging, while the EVIDENT SZX16 research stereomicroscope supports ergonomic oocyte preparation and embryo handling. Together, these systems form a coherent microscopy solution for assisted reproduction workflows.
View BX53 specifications and download brochure
View SZX16 specifications and download brochure
Contact our IVF microscopy experts
Reproductive Health Assay Menu & Diagnostic Solutions
Beckman Coulter offers a comprehensive portfolio of assays to screen, diagnose, and treat female-specific and age-related conditions avaible on Beckman Coulter Immunoassay analyzers - See also the Clinical Utility of Automated AMH Technology Discover more about immunoassays for reproductive health
- hLH
- Inhibin A
- Inhibin B (ELISA)†
- PAPP-A†
- Progesterone
- Prolactin
- Sensitive Estradiol
- Unconjugated Estriol
- SHBG
- Testosterone
- Total βhCG (5th IS)
- AFP (ONTD)
- AMH†
- DHEA-S
- hFSH
Our Product Categories in In Vitro Fertilization (IVF)
Our products
The MIRI® Time-Lapse Incubator is a multiroom incubator with a built-in camera and microscope. Designed and manufactured in EU, the MIRI® Time-Lapse Incubator provides high quality time-lapse images of embryos developing in "real-time" without having to remove the embryos from the safety of the incubation chamber for manual microscopy. Time-lapse embryo monitoring provides detailed morphokinetic data throughout embryo development, which is not available on routine spot microscopic evaluation. This allows all important events to be observed, helping IVF labs to identify healthy embryos with the highest probability of implantation, with the aim of achieving higher pregnancy rates.
FEATURES:
Completely independent chambers
6 (TL6) / 12 (TL12) independent chambers with precise temperature and gas regulation: Opening any chamber does not affect the environment in other chambers.
Time-lapse monitoring
Time-lapse video generated from images allows objective and reliable scoring and annotation of embryos for better prediction of future developmental and implantation potential
Heated lid
Excellent uniformity between the top and bottom lid.Heated chamber lids prevent condensation, enhance temperature regulation/recovery, and ensure temperature uniformity between the top and bottom of the chamber.
Fast temperature and gas recovery
• Temperature recovery <1 min
• Gas recovery <3 mins.
Superior gas system
• Built-in gas mixer for tri-gas, an advanced gas regulation system, and HEPA-VOC filtered recirculation allows precise gas level control and a lower gas consumption.
• UV-sterilization of recirculating gas ensures biological safety of embryos.
Easy external gas and temperature validation
Gas sampling ports for each chamber and independent PT-1000 sensors allow external quality evaluation of gas levels and temperature in each chamber.
User friendly interface
Touchscreen control panel with intuitive menu to manage configuration of the device
The CultureCoin
Specially designed culture dish, the CultureCoin, allows each chamber to culture 14 embryos, giving a total capacity of 84 embryos for the TL6 and 168 embryos for the TL12.
MIRI® TL Data Logger
Continually monitors and documents gas flow, gas concentration and pressure, temperature regulation.
Continuous pH monitoring
Optional SAFE Sens integration for continuous pH monitoring without opening the chamber.
MIRI® TL Viewer software and MIRI® TL Data Server
• Exponentially increase image and data storage capacity by adding the MIRI® TL Data Server.
• Combine MIRI® TL Viewer software platform to review, annotate and compare morphokinetic parameters of embryos, as well as export data for retrospective analysis.
Advanced upright fluorescence microscope tailored for life science research and clinical diagnostics.
Designed for flexibility and precision, the BX53 offers a modular semi-motorized platform ideal for fluorescence imaging, brightfield, and specialized contrast techniques.
- High-luminosity True Color LED illumination ensures consistent color temperature across all modes
- Modular system: motorize only what you need (focus, condenser, nosepiece)
- Compatible with a wide range of contrast methods including fluorescence, DIC, and polarization
- Integrates with Olympus / Evident X Line objectives for exceptional flatness, contrast, and chromatic correction
- Easily configured for educational, clinical, or research multi-user environments
Ideal for biomedical labs, tissue analysis, and pathology. Contact Analis experts in Belgium, the Netherlands, or Luxembourg for tailored advice and setup.
High-Precision Imaging for Advanced Reproductive Research
Why Choose the IX73 for ICSI/IMSI?
- Designed for IVF: Optimized for ICSI, IMSI, and SL-ICSI techniques.
- Improved Workflow: Motorized switching between objectives and condenser positions with one-button operation.
- High-Contrast Imaging: Supports relief-contrast and differential interference for clear oocyte and sperm visualization—even in plastic dishes.
- Effortless Operation: Focus and brightness automatically adjust with magnification changes.
- Expandable Configuration: Compatible with third-party micromanipulators and accessories.
Application Highlights
ICSI (Intracytoplasmic Sperm Injection)
IMSI (Intracytoplasmic Morphologically Selected Sperm Injection)
SL-ICSI (Spindle Localization)
Key Features
- Semi-motorized microscope with motorized switching of condenser/objectives
- Spindle observation standard (polarized light)
- One-button switching between observation methods via hand switch
- Supports IMSI with optional unit
- UIS2 optical system for superior image quality
- Compatible with relief contrast, DIC, and polarization techniques
Looking for full automation?
Inverted compound microscope for standard multicolor fluorescence and routine imaging.
The Olympus / Evident IXplore IX73 is optimized for high-quality imaging with ergonomic design.
- Fluorescence-ready system for cell culture and standard research tasks
- Same optical quality as high-end IXplore platforms
- Encoded upgrade path for improved reproducibility
- Simplified, intuitive operation for efficient workflow
- Modular build supports different vessels and observation techniques
Designed for consistent results in routine lab work. Contact Analis for full system integration.
Inverted Microscope for Live-Cell Imaging and Automation
Motorized and Modular Design for Precision Imaging
Seamless integration with Olympus cellSens software ensures intuitive operation, automated workflows, and consistent image acquisition across experiments.
Flexible Configurations for Time-Lapse and High-Content Applications
- Supports fluorescence, DIC, phase contrast, and IR-DIC imaging
- Motorized Z-drive and XY stage with TruFocus™ Z-drift compensation
- Modular deck structure for easy integration of additional optical paths or accessories
- Seamless compatibility with incubation systems for live-cell viability
- Ideal for cancer biology, stem cell tracking, and neuroscience research
- Scalable for routine imaging to AI-assisted image acquisition and automated analysis
The IXplore IX85 platform is also available in two optimized configurations:
- IXplore IX85 Pro for high-speed, high-content imaging with a wide field of view
- IXplore IX85 Live for long-term live-cell imaging with minimized phototoxicity and precise environmental control.
The MIRI® II Multiroom Incubator dedicates one chamber for one patient. IVF lab can choose from models having 6 or 12 chambers that are completely independent of each other. Any disruption on one chamber (e.g. temperature drop after opening the lid) has zero impact on the rest of the system. It has a touchscreen PC to control and monitor important parameters (temperature, gas concentration) simultaneously and give visual and audible alarm to signal critical conditions.
FEATURES:
1. One Chamber - One Patient
2. Superior gas system
3. Heated lid
4. Fast temperature and gas recovery
5. Touchscreen PC
6. Optimized heating plates
7. Easy external validation
8. Full-featured data logging software
SAFE Sens pH monitoring system for IVF culture media is integrated as a standard feature. In the US, every MIRI® II-12 unit will come equipped to easily turn on the pH monitoring feature. The SAFE Sens provides the following benefits over conventional pH tools:
(a) a decrease in time spent on pH protocols,
(b) data trending to optimize media pH equilibration time,
(c) having out-of-range email alert system, and
(d) being non-invasive due to the non-usage of petri dish and the constant opening of the incubator.
Multiroom incubator for embryo culture with 6 independent chambers, preventing cross contamination without causing any disturbance to the neighboring chambers even when the lids are opened/closed.
The MIRI is the actual standard system in new IVF labs.
DELIVERY INCLUDES:
-1 pc HEPA+VOC filter
-2 pcs External in-line filters
-2 pcs Fast connector with 15cm silicone tubing
-1 pc Data extension cable (1.5m)
-1 pc USB key with Data logging software
-1 pc power cable
-6 pcs heating optimization plates for Falcon, Nunc, or Vitrolife (please specify at the order the type of plate holder to be included)
FEATURES:
Six (6) completely independent chambers
Six independent MIRI® chambers, with precise temperature and gas regulation: Opening any chamber does not affect the environment in other chambers. Temperature or gas fluctuation caused by opening the lid have no impact on the rest of the system.
Superior gas system
Works with premix gas or 100% CO2 gas, with NDIR CO2 sensor to regulate CO2 levels. HEPA-VOC gas filtration system ensure clean gas recirculation
Heated lid
Heated chamber lids prevent condensation, enhance temperature regulation/recovery, and ensure temperature uniformity between the top and bottom of the chamber.
Fast temperature and gas recovery
Temperature recovery <1 min
Gas recovery <3 mins.
LED display
Large easy to read LED display and easy to navigate menu.
Optimized heating plates
Heating plate inserts to fit commonly used embryo culture dishes.
Easy external validation
Gas sampling ports for each chamber and independent PT-1000 sensors allow external quality evaluation of gas levels and temperature in each chamber.
MIRI® Data Logger
Continually monitors and documents gas flow, gas concentration and pressure, and temperature regulation.
Audible alarms for out of range parameters, with alarm logs documented in the Data Logger.
Space-saving the touchscreen tablet and stacking frame
Maximise the laboratory workplace by letting go of bulky computers and saving space with a tablet and a MIRI® stacking frame. Real time parameters such as temperature, gas concentration points, gas input pressures, gas flow rates, and even pH measurement can be conveniently viewed through the touchscreen tablet.
Continuous pH monitoring
Optional SAFE Sens integration for continuous pH monitoring without opening the chamber.
Advanced stereomicroscope platform for zoom imaging from whole organisms to cellular details.
The Olympus / Evident SZX16 offers a powerful zoom ratio and precision optics for complex life science research tasks.
- Zoom ratio of 16.4:1 enabling magnification up to 230x
- Apochromatic optics ensure clarity with minimized chromatic aberration
- Supports fluorescence, darkfield, brightfield, and polarization observations
- High NA objectives deliver up to 900 line pairs/mm resolution
- Ergonomically designed with ample working space for micromanipulation
Ideal for developmental biology, embryology, and neuroscience. Local support from Analis is available across Benelux.
Color digital camera optimized for clinical and life science imaging tasks.
The Olympus / Evident DP23 delivers high-quality color reproduction with ease of use.
- Crisp, clear imaging for routine documentation and teaching
- Enables live viewing and fast capture on large screens
- DP23-AOU option allows networked image sharing
- Compatible with Olympus microscopes and software
- Suitable for clinical, education, and research labs
A balanced choice for high-quality routine imaging. Available via Analis.
Versatile color camera for brightfield and fluorescence imaging in a single device.
The Olympus / Evident DP75 supports high-resolution imaging and complex staining applications.
- Supports wavelengths up to 1000 nm with switchable IR cut filter
- TruAI denoising enhances live image quality
- Vivid color reproduction with excellent sensitivity
- Streamlined capture of brightfield and fluorescence images
- Ideal for research labs needing multi-modal imaging
Optimize imaging with a single smart camera. Ask Analis for expert support.
Smart digital camera that transforms any microscope into a wireless teaching tool.
The Olympus / Evident EP50 enables collaborative viewing and digital streaming from microscope to screen.
- Full standalone configuration via tablet or PC
- Simultaneous WLAN and HDMI output
- Supports wireless sharing to monitors or projectors
- Designed for teaching, group learning, and live demonstration
- Easy integration with Olympus microscope systems
Empower classrooms and training with connected microscopy. Available through Analis.
Related
The MIRI® Time-Lapse Incubator is a multiroom incubator with a built-in camera and microscope. Designed and manufactured in EU, the MIRI® Time-Lapse Incubator provides high quality time-lapse images of embryos developing in "real-time" without having to remove the embryos from the safety of the incubation chamber for manual microscopy. Time-lapse embryo monitoring provides detailed morphokinetic data throughout embryo development, which is not available on routine spot microscopic evaluation. This allows all important events to be observed, helping IVF labs to identify healthy embryos with the highest probability of implantation, with the aim of achieving higher pregnancy rates. FEATURES: Completely independent chambers 6 (TL6) / 12 (TL12) independent chambers with precise temperature and gas regulation: Opening any chamber does not affect the environment in other chambers. Time-lapse monitoring Time-lapse video generated from images allows objective and reliable scoring and annotation
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