Optimize Microbial Screening with Beckman Coulter Microbioreactors
Accelerate Strain and Process Development
The stand-alone and integrated Beckman Coulter microbioreactors are designed to accelerate the screening of microbial strains, media formulations, and bioprocess conditions.
They provide real-time monitoring of:
- Biomass
- Fluorescence
- pH
- Dissolved oxygen (DO)
- Additional key cultivation parameters
Automation of sampling and liquid handling increases walk-away time, simplifies data analysis, and improves experimental reproducibility.
BioLector XT — Real-Time Cultivation Insights
The BioLector XT microbioreactor enables real-time evaluation of biomass, fluorescence, pH, dissolved oxygen in the liquid phase, and other cultivation parameters for:
- Aerobic microorganisms
- Anaerobic microorganisms
- Phototrophic microorganisms
Built on the proven BioLector Pro platform, the BioLector XT uses a standard ANSI/SLAS (SBS) microtiter plate format and operates with online, pre-calibrated optical sensors.
Disposable 48-well microtiter plates (MTPs) allow continuous online measurement of cultivation parameters. Patented microfluidic technology enables simultaneous pH control and feeding.
The optional microfluidic module eliminates manual liquid handling. No tubing or pipetting is required — all functions are integrated into the gamma-irradiated, ready-to-use plate.
Full Automation: BioLector XT & Biomek i-Series Integration
Integration of the BioLector XT with a Biomek i-Series liquid handler transforms the system into a fully automated screening platform.
This integration enables:
- Automated sampling and harvesting
- Automated inoculation
- Automated induction
- Bolus feeding and repeated fed-batch strategies
- Induction profiling
- Microbial growth synchronization
- Feed profiling
- Media preparation
- Automated upstream processing
The result is increased walk-away time and enhanced consistency in strain and process screening workflows.
Learn more about Biolector XT integration with Biomek
BioLector XT Video Overview
Explore the instrument architecture and workflow capabilities in the BioLector XT video overview.
Unlock the Full Potential of BioLector Solutions for Your Laboratory
Innovative Gassing Head – Precision Control Under Any Condition
The new gassing head expands experimental flexibility and process control:
Enables fed-batch experiments under anaerobic conditions
Adjustable O₂ supply from 1% to 100% and CO₂ from 1% to 12%
Significantly reduces gas consumption to just a few mL per minute
Optional gas humidification to minimize evaporation
Optional Microfluidic Module – Advanced Process Control
Take your BioLector XT to the next level:
Complements online monitoring with well-specific pH control and feeding
Supports 2 reservoir wells per 4 cultivation wells
Microvalves dispense liquids at the nanoliter scale
Eliminates manual liquid handling – no tubing, no pipetting
Plug-and-Play Plate Design
Real-time kinetics from 32 or 48 parallel cultivations
Customizable feeding strategies: batch, fed-batch, bolus, continuous*
On-plate pH control via pre-calibrated optical sensors*
Small working volumes: 800–2400 µL
*Requires optional microfluidic module
Intelligent BioLection Software
Designed for modern research environments:
Intuitive interface suitable for multi-user labs
Free programming of all control parameters
Open architecture for live data export
Fast processor for rapid data acquisition
Accelerate Bioprocess Development with High-Throughput Microbioreactors
The BioLector XT microbioreactor enables real-time monitoring of:
- Biomass (broad OD range)
- Fluorescence
- pH
- Dissolved oxygen (DO)
Additional key cultivation parameters
Compatible with aerobic, anaerobic and phototrophic microorganisms, the system is based on the standard ANSI/SLAS microtiter plate format and uses pre-calibrated optical sensors for reliable online measurements.
Disposable 48-well plates integrate patented microfluidics for simultaneous pH regulation and feeding. Ready-to-use, gamma-irradiated plates eliminate complex setup and reduce contamination risk.
Key Advantages for Microbial Cultivation
Up to 48 parallel fermentations in a single microtiter plate
Comprehensive online monitoring of biomass, fluorescence, DO and pH
NEW: Precisely controlled oxygen supply (0–100% O₂) via gas-tight lid*
Fed-batch capability (aerobic or anaerobic) with well-specific pH and feeding control*
Fully automatable for complex DoE workflows, sampling and screening
Typical Applications
Vaccine development
Fed-batch optimization*
pH profiling*
Feeding strategy optimization*
Media screening and formulation
Cultivation parameter optimization
Cell line and strain screening
Synthetic & systems biology
Anaerobic, aerobic and microaerophilic cultivation
Statistical Design of Experiments (DoE)
Growth characterization
High-throughput protein expression
Enzyme and activity assays
Functional genomics
Proteomics
Inhibition and toxicity testing
Quality control
Explore In-Depth Insights: Application Notes and Publications
BioLector Microbioreactor List of Publications.
Anaerobic cultivation processes of probiotic bacteria in the BioLector XT microbioreactor.
