Ensure Product Quality, Safety, and Regulatory Compliance
Particle counting is a critical tool for ensuring product quality, operational safety, and regulatory compliance across multiple industries. It supports process consistency, enables optimization, and contributes to reliable outcomes in both manufacturing and research environments.
Multisizer 4e – Advanced Particle Sizing and Counting
The Multisizer 4e is a highly accurate and flexible particle characterization system, offering an exceptional sizing range from 0.2 to 1600 μm.
Based on the Coulter Principle, it detects particles through electrical sensing rather than optical methods, making it independent of particle composition or optical properties.
Key Capabilities:
- High-precision particle counting and sizing
- Broad applicability across particle types
- Reliable detection regardless of transparency or color
Typical Applications:
- Mammalian cells
- Bacteria and yeast
- Cell aggregates
- Abrasives
- Toner particles
- Synthetic and industrial particles
What is the Coulter Principle?
The Coulter Principle is based on the detection of particles passing through a small aperture (sensing zone) filled with an electrolyte solution.
How it Works:
- An aperture (a precisely engineered glass tube with a micro-orifice) is placed between two electrodes.
- A stable electrical current flows through the electrolyte.
- When a particle passes through the aperture, it displaces an equivalent volume of electrolyte.
- This displacement causes a temporary change in electrical resistance (impedance).
- The system records this change as a pulse:
Each pulse = one particle counted
Pulse amplitude = particle volume
The measured signal allows determination of:
- Particle count
- Particle size (expressed as equivalent spherical diameter)
- Particle size distribution
A Versatile, Non-Optical Measurement Technique
Unlike optical systems, the Coulter Principle does not depend on particle transparency, refractive index, or composition. This makes it highly versatile for analyzing:
- Biological samples
- Microorganisms
- Industrial and synthetic materials
Applications Across Industries
The Multisizer 4e is widely used in:
- Pharmaceuticals – formulation control, particle sizing
- Biotechnology – cell counting and characterization
- Materials Science – powders, suspensions, and dispersions
Its high precision and reproducibility make it a valuable tool for quality control, R&D, and advanced analytical workflows.
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What applications are covered by the Multisizer in Life Sciences?
The Multisizer is an ideal tool for detecting and counting a wide variety of particles, such as:
Mammalian cells (cell counting, cell sizing and monitoring of the cell volume)
Bacteria
Yeast
Abrasives
Toner particles
Cell aggregates
Spheroids
Large protein aggregates
Particle Counting in Cell Biology
Particle Counting in Microbiology
