Enhancing Macromolecule Characterization: Trustworthy Insights with the Optima™ AUC System
Beckman Coulter introduced the first AUC sample characterization instrument to help the scientific community power new discoveries. That tradition continues into the 21st century with the new Optima™ AUC system. This latest tool is the most robust technology for providing data used to determine protein molecular weight in basic protein research and quantification of aggregation levels for academic and biopharmaceutical research.
AUC is referred to as an orthogonal method to characterize exosomes, AAV, viral vectors, and virus load characterization.
Optima™ AUC
Enables characterization of samples in their native state
A specialized ultracentrifuge with unique detection capabilities
Monitors a wide variety of particles
No standards required: relies on first principles of thermodynamics
Want to learn more about analytical ultracentrifugation? Take a more in-depth look at our AUC Resources Section.
Multiple orthogonal techniques in one instrument
The Optima AUC is a versatile tool for your lab with the ability to use:
Sedimentation Velocity (SV)
Density Gradient Equilibrium (DGE)
Analytical Band Centrifugation (ABC)
Sedimentation Equilibrium (SE)
Each of these operate based on different principles and provide complementary information. With the Optima AUC, you have the flexibility to choose experiment type(s) based on the answer you need. For example, an AAV workflow could include DGE for rapid, high-throughput quantification of particle fullness for in-process samples and SV could be used for attaining the highest resolution answers, including aggregation, necessary for final lot release.
You can use the same hardware across experiments, so think of the Optima AUC as your all-in-one separations toolbox.
Are you interested in harnessing the potential of lipid-based drug delivery systems?
Lipid nanoparticles (LNPs) have revolutionized the delivery of bioactive molecules, including oligonucleotide-based vaccines and gene therapies. They offer increased drug stability, higher bioavailability, and optimized drug distribution compared to conventional delivery methods.
Analytical ultracentrifuges analyze a wide array of particles in native, matrix-free condition and provides crucial data on parameters such as LNP morphology, mass, diameter, heterogeneity, mRNA loading ratio, and purity. All Optima systems have a high radial resolution and excellent signal-to-noise ratios, and enable the rapid and precise analysis of complex systems at discrete wavelengths for robust LNP formulation characterization.
We are thrilled to introduce Beckman Coulter Life Sciences’s whitepaper titled “A General Guide to Lipid Nanoparticles”.
A General Guide to Lipid Nanoparticles
In this comprehensive guide, you will explore the advantages of LNPs and their role in delivering mRNA, siRNA, and pDNA. Learn how LNPs can overcome degradation, renal clearance, and immune responses, enabling effective and targeted therapies. LNPs have played a significant role in the development of COVID-19 vaccines, protecting the mRNA payload from degradation, and ensuring its efficacy. They have also been instrumental in delivering gene therapies for the treatment of diseases like hereditary amyloidogenic transthyretin amyloidosis.
Our products
Optima AUC Analytical Ultracentrifuge package with Absorbance and Interference optics, Starter Kit (1 Counter balance, 1 Torque stand, 1 Quartz cell, 1 accessory kit) and 1 AN-50 rotor.
Beckman Coulter introduced the first AUC sample characterization instrument to help the scientific community power new discoveries. That tradition continues into the 21st century with the new Optima™ AUC system.
This latest tool is the most robust technology for providing data used to determine protein molecular weight in basic protein research and quantification of aggregation levels for academic and biopharma research.
Features :
Improved Data Quality
Higher radial resolution
Better signal to noise ratio than ProteomeLab
11x more vertical pixels for interference optics
Enables precise analysis of complex systems at discrete wavelengths (up to 20) in minimal time
Analyzes a wide array of particles in native, matrix-free conditions, including:
Proteins, Nanoparticles, LNPs, Peptides, Polymers, Micelles, Liposomes, Extracellular vesicles, Drug conjugates, Viral payload
Provides data which can answer more critical questions than any other comparable technique, including:
Shape, Mass, Diameter, Stoichiometry, Heterogeneity, Association, Aggregation, Purity, Formulation
Easier to Use
User-friendly touchscreen display indicates intuitive progression of experimental design.
Remote monitoring capabilities let you set up, monitor and extract data from virtually any location.
Compatibility with ProteomeLab XL cells and rotors
Toggle optics expedite workflow preparation.
This vacuum grease is for o-ring lubrification. Lubrification will protect the o-ring and maintain efficiency of the closure systems.
Silicon vacuum grease is used on the O-rings of centrifuges and ultracentrifuges to:
- Prevent Sample Spillage and contamination:
The grease helps maintain a tight seal, preventing any sample from leaking out and ensuring no contaminants enter the system. - Maintain Vacuum:
In devices like ultracentrifuges that operate under vacuum, the grease helps maintain the vacuum conditions by preventing air leaks into the centrifuge vessel. This is crucial for the proper functioning of these machines.
946-mL bottles of Solution 555™ Rotor Cleaning Concentrate, 1 qty; minimum order 2 bottles.
Under normal use, as part of the day-to-day care and maintenance program of the centrifuge rotors, wash the rotor frequently to prevent the build-up of residues.
Beckman Solution 555 (339555) is a mild and efficient detergent that won’t damage the rotors.
